Treatment and Prevention

Novostat tablets: instructions for use

In the form of tablets Novostat is not available, it is a non-existent form of the drug. It is produced only in the form of capsules. The drug has a pronounced hypolipidemic effect, is used in medicine to normalize cholesterol levels and as an anti-sclerotic agent.

Existing forms of production and composition

The drug is available in capsules, the active substance in them is represented by atorvastatin calcium trihydrate.

The body of the capsules is white and solid, the lid has a beige-yellow color. The main component here is contained in the amount of 10, 20, 40 or 80 mg. Additional composition is represented by lactose monohydrate, sodium lauryl sulfate, cellulose, calcium carbonate, povidone, and magnesium stearate. The capsule itself is made of gelatin with the addition of titanium dioxide and dye E172.

Cell packs contain 10 capsules and are distributed in boxes in the amount of 3 blisters.

Cell packs contain 10 capsules and are distributed in boxes in the amount of 3 blisters. Capsules can be sold in polymer jars of 10, 20, 30, 40, 50, 60 or 100 pieces. In cardboard packs placed in 1 such a bank.

International non-proprietary name

INN of the drug - Atorvastatin.

ATH

The drug has an ATC code C10AA05.

pharmachologic effect

The therapeutic effect of Novostat is provided by the active component - atorvastatin. This compound belongs to statins and exhibits cholesterol-lowering properties. It inhibits the activity of HMG-CoA reductase, acting as a competitive inhibitor with selective action. The specified enzyme is the beginning of the mevalonatnogo biosynthesis pathway of steroids, one of whose derivatives is cholesterol.

The therapeutic effect of Novostat is provided by the active component - atorvastatin.

Atorvastatin also contributes to an increase in the number of specific hepatoreceptors, leading to increased dissimilation of low-density lipoproteins (LDL). Due to the work of the drug decreases the concentration:

  • total cholesterol - 40% (on average);
  • apoB - by 51%;
  • LDL - 42%;
  • triglycerides - by 24%.

At the same time, there is an increase in indicators of high-density cholesterol-lipoproteins (HDL) and apoA.

This medicine is also effective for patients with a homozygous form of familial hypercholesterolemia, which is insensitive to the action of other lipid-lowering drugs. As a result of the intake, the likelihood of developing strokes, other cardiovascular ailments, ischemia for angina and heart attack, cardiovascular mortality is reduced. No carcinogenic or mutagenic effect was found.

Pharmacokinetics

Atorvastatin is rapidly absorbed in the gastrointestinal tract, reaching a maximum concentration in the blood plasma within 1-2 hours after administration, but its bioavailability does not exceed 14% due to impaired absorption and the "first-pass" phenomenon. About 98% bind to blood proteins, so hemodialysis is useless. In the presence of food, the rate of drug entry into the blood slows down.

With liver damage, atorvastatin concentration increases greatly.

Metabolization of the drug occurs mainly in the liver. According to the pharmacological activity of some of its metabolites are not inferior to the original substance - they account for about 70% of the inhibitory effect on HMG-CoA reductase. No more than 2% of the accepted dose is excreted with urine.

With liver damage, atorvastatin concentration increases greatly. The half-life of the drug is 14 hours, but the therapeutic effect lasts up to 30 hours after taking 1 dose of Novostat.

Indications for use

In combination with diet therapy and exercise therapy, the drug is prescribed to obtain the lipid-lowering effect of statins - lowering cholesterol, LDL, fighting elevated concentrations of apolipoprotein B and triglyceride compounds. Indications for use:

  • hypercholesterolemia (primary, familial, or non-hereditary);
  • hyperglyceridemia;
  • combined hyperlipidemia:
  • violation of lipoprotein metabolism;
  • Type II dysproteinaemia (a and b);
  • Fredrikson type IV lipid pathology, which is resistant to dietary treatment;
  • dysbetalipoproteinemia and related abnormalities.
The drug is also applicable to patients with hypercholesterolemia in the secondary prevention of stroke.
The drug is prescribed in violation of lipoprotein metabolism.
In combination with diet therapy and exercise therapy, the drug is prescribed to obtain the lipid-lowering effect of statins - lowering cholesterol.
The drug is prescribed, if necessary, measures to restore the vascular wall.
Another remedy is prescribed for the prevention of cardiovascular diseases, regardless of cholesterol indices for smokers.

Another remedy is prescribed for the prevention of cardiovascular diseases, regardless of cholesterol parameters:

  • diabetics;
  • smokers;
  • hypertensive patients;
  • patients with low HDL;
  • people with a genetic predisposition to diseases of the cardiovascular system.

The drug is also applicable to patients with hypercholesterolemia in the secondary prevention of strokes, heart attacks, strokes, congestive heart failure, and to reduce the likelihood of death. Also, the drug is prescribed, if necessary, measures to restore the vascular wall (revascularization).

Contraindications

The drug should not be taken in case of hypersensitivity to atorvastatin, lactose intolerance or other components of the drug. Other contraindications:

  • liver disease;
  • increased liver enzyme activity;
  • chronic alcoholism;
  • severe infections in acute form;
  • metabolic disease;
  • severe physical weakness;
  • pregnancy and breastfeeding;
  • age up to 10 years.

Novostat prohibited from severe physical weakness.

Carefully

Particular caution should be exercised in the presence of electrolyte imbalance, endocrine disruptions, hepatic abnormalities in history. It is not recommended to prescribe Novostat to children and adolescents.

How to use

You must first try to normalize cholesterol in other ways, and also pay attention to the treatment of the underlying pathology and lose weight (with obesity or a tendency to it).

Capsules drink regardless of the time of day and meals. The therapeutic effect is not achieved immediately - it should take at least 2 weeks from the start of the reception of Novostat. And only after 4 weeks, the effect will be maximum and will remain so until the end of the therapeutic course. The doctor prescribes the dosage and monitors the patient's condition. The daily dose depends on the level of cholesterol, therapeutic goals and individual reactions to treatment.

Plasma lipid concentrations are regularly monitored and medication intake is adjusted. For prophylactic purposes, the drug is used in a minimum dose.

With diabetes

Statins lead to a slight increase in glucose concentration, which is easily compensated by diet, exercise and usual antidiabetic agents. Dose adjustment is not required.

Capsules drink regardless of the time of day and meals.

Side effects

Various undesirable reactions may occur.

From the senses

Auditory abnormalities.

Musculoskeletal and connective tissue

Myopathy, myositis, arthralgia, muscle cramps.

Gastrointestinal tract

Dyspepsia, anorexia, diarrhea, pancreatitis.

Hematopoiesis

Decreased platelet concentration.

central nervous system

Migraines, insomnia, neuropathy, paresthesias, skeletal muscle weakness, dizziness.

On the part of the urinary system is the weakening of erection.

On the part of the respiratory system

Bronchospasm.

From the genitourinary system

Weakening of erection, renal failure.

Since the cardiovascular system

Rectal bleeding.

Metabolism

Changes in blood sugar levels.

In rare cases, pills can lead to baldness.

Allergies

Urticaria, baldness, anaphylaxis.

Influence on ability to operate mechanisms

Should refrain from classes that require concentration.

special instructions

Do not apply for weight loss - the drug does not possess such properties.

Use in old age

There is no need to change dosages.

There is no need to change dosages in old age.

Appointment to children

You can not prescribe the drug to children under 10 years. It is used for hyperlipidemia, if the child is at risk or has a congenital predisposition to cardiac pathologies with a high mortality rate. The drug is used with low efficiency of diet. You should first undergo a course of exercise therapy and treat the underlying disease. High risk of myopathy.

Use during pregnancy and lactation

The drug should not be taken by pregnant women and women of reproductive age, the probability of becoming pregnant in which is high due to the neglect of contraception. Nursing mothers are also not prescribed the drug until complete cessation of breastfeeding.

Use in violation of the liver

Severe pathologies of the liver structures and increased transaminase activity are a strict contraindication to receive Novostat.

Overdose

Possible violation of the liver and rhabdomyolysis. It is recommended to wash the stomach and take the sorbent. Treatment is only symptomatic.

In case of overdose, liver malfunction may occur.

Interaction with other drugs

The simultaneous use of Novostat with Erythromycin, Cyclosporine, Niacin, azoles and fibric acid preparations increases the risk of myopathy. High doses of the drug can cause a jump in the concentration of digoxin. Erythromycin, Clarithromycin and grapefruit juice increase atorvastatin levels. It is possible to change the pharmacodynamic parameters of ethinyl estradiol and norethisterone contraceptives. In the presence of Colestipol, the hypolipidemic indices of both drugs are mutually enhanced.

Compatibility with alcohol

It is recommended to refrain from drinking.

Analogs

The active ingredient of Novostat is included in the composition of such preparations:

  • Atorvastatin;
  • Atoris;
  • Torvacard;
  • Tulip;
  • Livostor;
  • Atorvakor and others.

The active ingredient of Novostat is part of Tulip.

Novostat release conditions from the pharmacy

In the free access of the drug is missing.

Can I buy without a prescription

It is released only upon presentation of a prescription.

Price

10 mg capsules cost from 60 rubles. for 10 pcs.

News storage conditions

The drug should be stored at temperatures up to + 25 ° C away from sunlight.

Shelf life

3 years.

Manufacturer

In Russia, Novostat is manufactured by CJSC ALSI Pharma and CJSC Biocom.

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Novostat Reviews

Polina, 24 years old, Lipetsk

The drug was prescribed grandfather because of high cholesterol. He drank the medicine for a long time, his condition improved. Only it was necessary to constantly monitor that grandpa did not break the diet. They were satisfied with the action of the drug, there were no complaints about side effects.

Olga, 54, Vyazemsky

Because of high cholesterol, I had to take these capsules, and regularly go to the hospital, often take tests and go on a diet. There were no adverse reactions. Or maybe they were weak, and I did not pay attention. The state of health began to improve somewhere in a week. After drinking the entire course, for the first time in a long time I can say that I feel good.

Watch the video: What are the Side Effects of Cholesterol-Lowering Medications? (November 2019).

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