Over the past decades, the incidence of diabetes mellitus, in particular its second type, has increased. The situation is associated with the deterioration of the economic situation in the world, ignoring the rules of nutrition and the constant stresses experienced by people.
Diabetes mellitus reduces the quality of the blood vessels of the whole organism, therefore the risk of formation of pathologies of vascular origin increases. The most dangerous diseases of such etiology are strokes and heart attacks.
There is a need for a complex effect on the human body and the creation of therapy, taking into account the peculiarities of the disease. Actovegin is a drug that allows you to speed up the metabolism of glucose and oxygen in the body. The raw material for the drug is the blood of calves under the age of eight months. Actovegin should be applied, strictly adhering to the instructions.
What is the Actovegin
Actovegin has long been successfully used in a therapeutic complex against sugar dibet and other pathologies. This drug is included in the group of drugs that improve the metabolism of tissues and organs.
Stimulation of metabolism occurs at the cellular level, due to the accumulation of glucose and oxygen in the tissues.
Actovegin is a purified dispersion that is obtained from the blood of calves. Due to the fine filtration, the drug is formed without unnecessary components. This suspension does not contain protein components.
The drug contains in its composition a certain number of trace elements, amino acids and nucleosides. It also has intermediate products of lipid and carbohydrate metabolism. These components release ATP molecules during processing.
The main trace elements of the drug can include:
These components are involved in the process of ensuring normal brain function, as well as cardiovascular activity. The drug does not contain components that can cause allergic reactions.
The use of Actovegin has been going on for more than 50 years, and the tool does not lose its popularity. The drug improves energy metabolism in tissues, which is possible due to:
- increase in phosphates, which have a high energy potential,
- activating the enzymes involved in phosphorylation,
- increased cell activity
- increased production of proteins and carbohydrates in the body,
- increase the rate of glucose decomposition inside the body,
- the launch of the mechanism of activation of enzymes that break down sucrose, glucose.
Due to its properties, the drug Actovegin is recognized as one of the best medicines of a complex action for the second type of diabetes. In particular, it has the following advantages:
- reduces neuropathy,
- ensures the appearance of a normal reaction to sugar,
- eliminates pain in the legs and arms, which allows a person to move freely,
- reduces the feeling of numbness
- improves tissue regeneration
- activates the exchange of energy components and useful elements.
Impact on diabetes
In type 2 diabetes, Actovegin acts on a person like insulin. This effect is due to the presence of oligosaccharides. With the help of them, the work of glucose carriers, of which there are about five species, is resumed. Each of them needs its own approach, which Actovegin does.
The drug accelerates the transport of glucose molecules, supplies cells with oxygen, and also has a positive effect on the work of the brain and blood circulation in the vessels.
Actovegin makes it possible to restore glucose. If the amount of glucose is not enough, the tool improves the general well-being of the patient and the activity of his physiological processes.
Quite often Actovegin is used for diabetes mellitus of the second type, if there is insufficient blood coagulability, wounds and scratches slowly heal. The drug is effective for burns 1 and 2 degrees, radiation problems and bedsores.
The drug is different effects that are found at the cellular level:
- lysosomal cell activity and acid phosphatase activity are improved,
- alkaline phosphatase activity is activated,
- the influx of potassium ions into the cells is improved, there is an activation of potassium-dependent enzymes: sucrose, catalase and glucosidase,
- normalized intracellular pH, the decomposition of anaerobic glycolase products becomes faster
- hypoperfusion of organs is eliminated without negative effects on systemic hemodynamics,
- The functioning of antioxidant systems on a clinical model of acute myocardial infarction is preserved.
Actovegin and complications of diabetes
In diabetes mellitus, people often suffer from various complications with which this drug effectively works. The use of Actovegin intravenously, makes it possible to accelerate the healing process of wounds and restore the functions of organs.
The tool also reduces the risk of stroke. With the help of Actovegin, the viscosity of the blood is reduced, the cells are equipped with oxygen, and the progression of complications is limited.
The drug Actovegin is also used if a person has problems with the cornea of the eyes. Actovegin is prescribed exclusively by the attending physician after a thorough examination of the body and the performance of the necessary tests.
The treatment strategy should take into account the characteristics of the patient.
Particular attention should be paid to the possibility of intolerance to some components of the tool to avoid complications.
Instructions for use of the drug
The drug Actovegin can be administered orally, topically and parenterally. The last route of administration is the most effective. The agent can also be administered intravenously. 10, 20 or 50 ml should be diluted with glucose solution or saline.
The course of treatment includes 20 infusions. In some cases, the drug is prescribed for two tablets three times a day. Actovegin should drink a small amount of clean water. The remedy is applied topically in the form of an ointment or gelatinous gel.
The ointment is used as a treatment for burns or wounds. In the treatment of trophic ulcers in diabetes mellitus, the ointment is applied in a thick layer. The affected area is covered with a bandage for several days. In the case of moist ulcers, the dressing should change every day.
In accordance with the instructions, Actovegin in diabetes mellitus of the second type is prescribed, if any:
- old head injuries
- complications on the background of ischemic stroke,
- vascular tone reduction,
- violation of the nutrition and condition of the skin,
- various ulcers,
- dead skin and burns.
Produces the drug company Nycomed, which provides a guarantee of safety of the drug. The drug does not cause dangerous complications. The tool is made from the blood of animals that come from countries that are safe in the matter of infection and rabies.
Raw materials are carefully monitored in accordance with international standards. Blood calves are supplied from Australia. WHO recognizes Australia as a country where there is no epidemic of spongiform encephalopathy of these animals.
The technology of the drug is aimed at eliminating infectious agents.
Medicine has been using this drug for several decades, it has mostly positive patient reviews.
Analogs and cost of the drug
Actovegin sold in the range of 109 to 2150 rubles. The price depends on the form of release of the drug. One of the known analogues of Actovegin is the drug Solcoseryl. This drug is produced in the form of creams, ointments and injection solutions.
The advantage of this tool is almost complete identity with Actovegin. The drug has an active substance - dialysate, purified from protein. The substance is also obtained from the blood of young calves.
Solcoseryl is used to treat diseases that are caused by a lack of oxygen in the cells, as well as the healing of burns and wounds of varying severity. Admission is undesirable during childbirth and breastfeeding. The cost of the drug ranges from 250 to 800 rubles.
Dipyridamole and Curantil improve blood circulation and can serve as an analogue of Actovegin in the treatment of peripheral vascular ailments. The cost of these medicines starts from 700 rubles.
Curantila 25 is the main substance dipyridamole. The drug is prescribed to treat various forms of thrombosis, it is also applicable for recovery after myocardial infarction. The tool is suitable for analogue Actovegin.
Curantil 25 is produced in the form of dragees, tablets or injections. The drug is strictly contraindicated in acute heart diseases, stomach ulcers, hypertension, disorders of the kidneys and liver, pregnancy and a high degree of sensitivity to the main substance. The average cost is 700 rubles.
Vero-Trimetazidine tablets are used in the treatment of cerebral ischemia. They have the most democratic cost, the price is only 50-70 rubles.
Cerebrolysin is an injectable drug that belongs to nootropic drugs and is used as an analogue to Actovegin in case of disorders of the central nervous system. The cost of Cerebrolysin ranges from 900 to 1100 rubles. The drug Cortexin improves brain metabolism, its price, on average, is 750 rubles.
A large assortment of Russian and foreign-made counterparts makes it possible to select a suitable and high-quality analogue to the drug Actovegin.
Nootropil is a drug that is widely used in medicine. Its main active ingredient is piracetam. Nootropil is considered a high-quality analogue of Actovegin. It is produced in the form of:
- injection solutions,
- syrup for children.
Nootropil effectively improves and restores the full operation of the human brain. This drug is used to treat a variety of pathologies of the nervous system, in particular dementia in diabetes. The tool has the following contraindications:
- liver failure,
- hypersensitivity to piracetam.
The average cost of the drug is in the range of 250 to 350 rubles.
Side Effects and Results of Use
In type 2 diabetes, it is important to follow all prescriptions. By following the instructions, you can use Actovegin effectively and safely. This drug does not cause unexpected dangerous reactions.
Treatment must necessarily take into account the level of sensitivity to drug preparations. If there is an individual intolerance to certain substances that are the basis of the drug, the doctor will not include this drug in the treatment regimen.
Medical practice knows cases when the use of the drug Actovegin became the cause of:
- increasing body temperature
- human feverish state.
In rare cases, Actovegin can reduce the activity of the cardiovascular system. This can be expressed in rapid breathing, high blood pressure, feeling unwell or dizziness. In addition, there may be a headache or loss of consciousness. When administered orally in case of dosing disorders, nausea, vomiting and stomach pain may occur.
The drug Actovegin is an effective tool in the fight against diabetes. This confirms the common practice of its use. The effect of the external use of the drug is expressed quite quickly, on average, after 15 days.
If during the process of therapy, a person has pain in different areas of the body, and there is a worsening of well-being, then you should consult with your doctor in a short time. Analyzes will be determined for the patient, which will show the reasons for the body's reactions.
The drug will be replaced by a drug that has similar medicinal characteristics.
Actovegin is forbidden to use for children under the age of 3 years and people who have a high sensitivity to the drug.
Also, it should not be applied to women during lactation and pregnancy. Use of Actovegin is not recommended for young mothers who have had problems with pregnancy.
It should be used with caution in people who have heart and lung problems. Also, the drug is forbidden to use for people with difficulties in the removal of fluid.
The drug Actovegin is an effective tool for the treatment of diabetes in the severe stages of the disease. With proper use and compliance with the recommendations of the doctor, this drug is completely safe for the body.
Thanks to Actovegin, glucose transport becomes faster. Each particle of the body can fully consume the necessary substances. The results of medical studies reported that the first effect of the use of the drug comes in the second week of therapy.