Treatment and Prevention

Drug Glemaz: instructions for use

The hypoglycemic drug Glemaz is prescribed to patients with type 2 diabetes mellitus and belongs to the group of III generation sulfonylurea derivatives. It is used to control the concentration of glucose in the blood.

International non-proprietary name

Glimepiride (glimepiride).

Hypoglycemic drug Glemaz is prescribed to patients with type 2 diabetes.

ATH

A10BB12.

Forms of release and composition

The drug is sold in the form of flat rectangular tablets of rectangular shape and light green color with 4 mg of glimepiride (active ingredient) in each. Secondary components: magnesium stearate, yellow quinoline dye, blue diamond dye, microcrystalline cellulose, croscarmellose sodium, cellulose.

In a blister made of aluminum / PVC 5 or 10 tablets. In a pack of cardboard made of 3 or 6 contour blisters.

pharmachologic effect

The drug belongs to the oral hypoglycemic group. Its active component stimulates the beta cells of the pancreas, increasing insulin production and suppressing gluconeogenesis. The drug reduces hyperglycemia without affecting the insulin concentration.

Extrapancreatic action of the agent is based on the increased sensitivity of peripheral tissue fibers to insulin. Hypoglycemic has anti-atherogenic, antiplatelet and antioxidant activity.

Pharmacokinetics

After taking 4 mg of the drug, the highest concentration of its active ingredient in the plasma is observed after 2.5 hours. Glimepiride has 100% bioavailability when ingested. Food does not significantly affect the pharmacokinetic properties of hypoglycemic.

About 60% of the drug is excreted by the kidneys.

About 60% of the drug is excreted by the kidneys, 40% by the intestines. In the urine is not detected substance in unchanged form. Its half-life is from 5 to 8 hours. When taking the drug in high doses in patients with impaired renal function (when creatinine clearance is less than 30 ml / min), there is an increase in clearance and a decrease in plasma concentration and action of glimepiride, which is caused by accelerated elimination of the drug due to weakening of its binding to plasma proteins.

Indications for use

The hypoglycemic agent is prescribed to patients with type 2 diabetes mellitus and can be used both in monotherapy and in combination with Metformin and insulin therapy.

Contraindications

Hypoglycemic is contraindicated in such conditions and disorders:

  • type 1 diabetes;
  • leukopenia;
  • severe renal impairment in patients undergoing hemodialysis;
  • severe liver pathologies;
  • in the minor age;
  • breastfeeding and gestation;
  • diabetic ketoacidosis and diabetic coma and precoma;
  • allergies to the composition of hypoglycemic drugs.

The drug is carefully prescribed for conditions that require the transfer of the patient to insulin therapy (deterioration of the absorption of drugs and food in the gastrointestinal tract, heavy surgery, burns and injuries).

The drug is not prescribed for type 1 diabetes.
For severe renal impairment, taking the drug is prohibited.
Glamase is prohibited for use in pathologies of the liver.
During gestation, Glemaz is not prescribed.
Perekoma is considered a contraindication to the use of the drug Glemaz.

How to take Glemase?

The drug is used orally. Reception of a daily dose has to occur in the course of food or to it. The pill is taken whole and washed down with half a glass of water.

With diabetes

In the early days, the drug is administered in doses of 1/4 tablet (1 mg of the substance) 1 time / day. In the absence of positive dynamics, the dosage may increase to 4 mg. In exceptional cases, it is allowed to exceed doses of 4 mg, but more than 8 mg of the drug are prohibited per day.

The frequency and number of doses per day is determined individually, taking into account the lifestyle of the patient. Long-term therapy involves regular monitoring of plasma glucose levels.

Glemaz side effects

On the part of the organ of vision

There is the likelihood of transient visual disturbances in the form of double vision and loss of clarity of perception.

Musculoskeletal and connective tissue

There is a risk of muscle spasms.

Gastrointestinal tract

Adverse reactions are manifested by a sense of discomfort and heaviness in the epigastric region, vomiting, nausea, increased liver enzyme activity and hepatitis.

Muscle cramps are a side effect of the drug.
Glamase causes nausea vomiting.
While taking the drug Glemaz may cause hepatitis.
Headache is considered a side effect of the drug.
Glamps can cause urticaria.

Hematopoiesis

In some cases, hemolytic and aplastic anemia, agranulocytosis, pancytopenia, erythrocytopenia and thrombocytopenia are observed.

central nervous system

In rare cases, there is a worsening of psychomotor reactions, headache, decreased concentration.

Metabolism

Hypoglycemic reactions develop, appearing shortly after using the medication. They may have a severe form.

Allergies

Patients may experience urticaria, pruritus, allergic cross-reactions with sulfonamides and other similar substances, as well as an allergic form of vasculitis during treatment with the drug.

Influence on ability to operate mechanisms

Considering that the drug can cause psychomotor disorders, it is strongly recommended to avoid the use of complex mechanisms during its reception.

special instructions

The occurrence of hypoglycemia in the process of using the drug in dosages of 1 mg suggests that glycemia can only be regulated through diet therapy.

In stressful circumstances, it may be necessary to temporarily transfer the patient to insulin therapy.

With inadequate nutrition while taking the medication increases the risk of hypoglycemia.

In stressful circumstances, it may be necessary to temporarily transfer the patient to insulin therapy.

Use in old age

Acceptance of hypoglycemic does not imply dose adjustment.

Appointment to children

In pediatrics, hypoglycemic agent is not used.

Use during pregnancy and lactation

During pregnancy, it is forbidden to use a hypoglycemic drug.

Use in violation of kidney function

In acute disorders of the organ, the drug is contraindicated.

Use in violation of the liver

It is contraindicated to use tablets in acute liver pathologies.

There may be signs of hypoglycemia in overdose.

Glemaz Overdose

You may experience signs of hypoglycemia (sweating, tachycardia, anxiety, heart pain, headache, increased appetite, depression).

Treatment involves an artificial challenge of vomiting, taking adsorbents and drinking heavily. In severe cases, the administration of a solution of dextrose is additionally prescribed, with careful monitoring of the glucose concentration. Further symptomatic measures.

Interaction with other drugs

With simultaneous use of the drug with oral hypoglycemic agents, anabolic steroids, Metformin, Insulin, Ifosfamide, Fluoxetine and a number of other medicines, an increase in hypoglycemic activity can be observed.

Under the influence of Reserpine, Guanethidine, Clonidine and beta-blockers recorded the absence or weakening of the symptoms of hypoglycemia.

Compatibility with alcohol

It is undesirable to mix with alcohol because of the unpredictable reaction of the body.

Analogs

Hypoglycemic drug can be replaced by such effective and affordable analogues:

  • Diameric;
  • Glimepiride canon;
  • Glimepiride;
  • Amaril.
Glimepirid in the treatment of diabetes
Amaril: indications for use, dosage
The sugar-reducing drug Amaril
Diabetes: Symptoms

Pharmacy vacation terms

Can I buy without a prescription?

Buy hypoglycemic can only prescription.

Price

For 30 tablets you need to pay the amount of 611-750 rubles.

Drug storage conditions

Keep hypoglycemic need to be away from sunlight, at low humidity and room temperature. Blister integrity (cracking) should not be compromised.

Shelf life

24 months.

Manufacturer

Company "Kimika Montpellier SA" (Argentina).

Reviews

Doctors

Victor Smolin (therapist), 41, Astrakhan.

This hypoglycemic drug today is not new in the pharmaceutical market. On sale you can find at least effective counterparts. However, this tool is preferred by many doctors, as its medicinal effect is verified by time itself.

Diameride is considered an analogue of the drug Glemaz.
Glimepiride Canon - an analogue of the drug Glemaz.
Glemase can be replaced by the drug Glimepirid.
Amaryl can be taken instead of the drug Glemaz.

Of patients

Alisa Tolstyakova, 47, Smolensk.

I have been taking these pills to stabilize glucose for a long time (about 3 years). During this period there were no side effects. The condition is consistently good, I do not plan to replace the medicine yet, and there is no need for that, because its value completely suits me.

Losing weight

Antonina Voloskova, 39 years old, Moscow.

With this drug, I was able to lose some weight. Despite the fact that I do not get sick with diabetes mellitus, its action allowed me to normalize the level of glucose in the blood, so that I began to burn fat more intensively. Good medicine. I bought several packages at once.

Watch the video: Para que sirve GLIMEPIRIDA: PresentaciĆ³n Dosis y Efectos secundarios. (November 2019).

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