Low molecular weight heparins (LMWH) are a class of anticoagulant drugs used to prevent and treat thromboembolic complications.
The range of application is quite wide, combines surgical and therapeutic profile, as well as emergency medicine.
Unlike its predecessor - Heparin, LMWH have pronounced pharmacological activity, are safer and more controlled, and can be administered either subcutaneously or intravenously.
To date, several generations of these drugs are on the market, which are constantly being supplemented with new drugs. This article will discuss Fraksiparin, the price and quality of which fully satisfy the needs of doctors and patients.
The active ingredient of Fraxiparin is nadroparin calcium, which is indicated in the following clinical situations:
- prevention of thrombosis in surgical patients;
- treatment of pulmonary embolism;
- treatment of thrombophlebitis of various origins;
- prevention of blood clotting during hemodialysis;
- in the complex therapy of acute coronary syndrome (heart attack).
It is important to note that Fraxiparin is used primarily in the hospital under the supervision of a physician. Before the appointment should perform a series of clinical and laboratory studies, in particular coagulogram.
There is no medicine that is suitable for all patients.
Before use, you should carefully read the instructions and establish whether you have the following contraindications:
- allergic reactions to calcium nadroparin or auxiliary components that are part of the solution;
- active bleeding or increased risk of its development;
- traumatic brain injury;
- pregnancy and lactation;
- severe renal failure;
- children under 18 years of age (relative contraindication).
Unlike Heparin, which has a natural antidote - Protamine Sulfate, LMWHs do not have one.
Fraxiparin is available as a subcutaneous or intravenous solution. Available in disposable sealed syringes with a protective cap, which are securely packed in 10 pieces per pack.
Solution for subcutaneous injection of Fraxiparin
It is usually injected subcutaneously, for which the syringe is removed from the shell and the cap is removed. The injection site (umbilical region) is treated three times with an antiseptic.
The skin fold is formed with the fingers of the left hand, the needle is inserted strictly perpendicular to the skin for the entire length. The syringe is removed, it is not suitable for reuse.
ManufacturerFraxiparin is a branded drug of the American pharmaceutical corporation Aspen.
This company has been on the market for more than 160 years, according to the data of 2017, it is among the ten world leaders in the production of medicines, medical and laboratory equipment.
The French companies Sanofi-aventis and Glaxosmithkline represent a wide variety of different dosages of nadroparin calcium, also under the trade name Fraxiparin.
In this case, the drug is a generic (bought the right to manufacture from Aspen). Nadroparin-Pharmex, which is manufactured by Pharmex Group, is available for sale on the territory of Ukraine.
Available in disposable syringes of 0.3, 0.4, 0.6 and 0.8 ml of 10 pieces in one pack.
The dose depends on the concentration of the active substance, nadroparin calcium, measured in international units.
1 ml of Fraxiparin contains 9500ME of the active ingredient.
Thus, in the 0.3 ml will be 2850ME. In such an amount, the drug is indicated for patients whose weight does not exceed 45 kg.
Contains 3800 IU of nadroparin calcium, is indicated for patients weighing from 50 to 55 kg.
Contains 5700ME active ingredient, suitable for patients from 60 to 69 kg.
The price of Fraxiparin depends on the dose and the manufacturer. It goes without saying that a branded drug is much more expensive than a generic.
Price Fraxiparin depending on the dosage:
|Dose in ml||The average price in Russia in rubles for 10 syringes|
|0,3||2016 ― 2742|
|0,4||2670 ― 3290|
|0,6||3321 ― 3950|
|0,8||4910 ― 5036|
Prices are averaged, presented for 2017. May vary by region and pharmacy.
About the course of thrombophlebitis in diabetes in the video:
Thus, Fraksiparin is an indispensable drug for the treatment and prevention of thrombosis. Among the advantages are a variety of available dosages, safety and reasonable cost.